buy anavar

 

Buy anavar hydrochloride – 25 mg. Excipients: benzalkonium chloride 0.1 mg disodium edetate dihydrate -1.0 mg Sodium hydroxide – 0.24 mg sodium disulfite – 3.0 mg, citric acid 1,0 mg sodium citrate dihydrate – 5.0 mg water for injection – up to 1 ml.

Description: clear, colorless or slightly colored solution.

 

Pharmacotherapeutic group:

α-adrenoagonists.

 

Pharmacological properties:


Pharmacodynamics

buy anavar – α-adrenoagonists, has a strong non-selective α-adrenomymeticheskoe action. When used in therapeutic doses has no significant stimulating effect on the central nervous system.
The local application in ophthalmology causes mydriasis, improves the outflow of intraocular fluid and constricts blood vessels of the conjunctiva.
Has little effect on β-adrenergic receptors, including the heart (no positive chrono and inotropic effects). The drug has vasoconstrictor action, such action of norepinephrine (noradrenaline). buy anavar pressor effect is weaker than that of norepinephrine, but is longer. Causes vasoconstriction after 30-90 seconds after installation, the duration of 2-6 hours.
After the installation of buy anavar causes contraction of muscles, dilates the pupil, thereby causing mydriasis. Mydriasis occurs within 10-60 minutes after a single installation. Mydriasis is maintained for 2 hours. Mydriasis caused fenylefrinrm not accompanied by cycloplegic.

Farmakokinetta
buy anavar: easily penetrates into the tissue of the eye, the maximum plasma concentration is reached 10-20 minutes after installation in the eye. Pre-installation of local anesthetics may increase the systemic absorption of buy anavar and prolong mydriasis.
buy anavar is excreted in the urine unchanged (<20%) or in the form of inactive metabolites.

Indications for use:
Iridocyclitis (for prevention of posterior synechia and reduce the exudation of the iris).
For diagnostic mydriasis with ophthalmoscopy and other diagnostic procedures necessary to monitor the posterior segment of the eye condition.
Conducting a provocative test in patients with narrow profile of the anterior chamber angle and suspicion of angle-closure glaucoma.
The differential diagnosis of superficial and deep injection of the eyeball.
“red-eye” syndrome (to reduce redness and irritated eye membranes).
spasm of accommodation.

Contraindications for use:
. Hypersensitivity to the drug
narrow-angle or angle-closure glaucoma.
Old age.
Severe cardio – vascular or cerebrovascular disease.
Violation slezoproduktsii.
Prematurity; Children under 6 years (spasm of accommodation).
Hyperthyroidism.
Hepatic porphyria.
Congenital deficiency of glucose-6-phosphate dehydrogenase.

Precautions for use:
Diabetes mellitus (risk of increased blood pressure associated with impaired autonomic regulation).
Old age in the absence of concomitant severe cardiovascular or cerebrovascular disease (increased risk of reactive miosis).
Concomitant use with monoamine oxidase inhibitors (including within 21 days after the termination of their use).
Serpovydno cell anemia, wearing contact lenses after surgery (reduction due to conjunctival wound hypoxia).

Pregnancy and lactation:
Action fenilefryna in pregnant women and breastfeeding are poorly understood, so use the drug in these categories of patients is possible only if the expected benefit to the mother outweighs the potential risk of the fetus or child. It is not known whether the drug is excreted in breast milk. In the appointment during lactation should stop breastfeeding during treatment.

 

Dosage and administration:

When iridotsiklitah drug is used to prevent the development and tear already formed posterior synechiae; to reduce the exudation into the anterior chamber of the eye. For this purpose, one drop preparation is dropped into the conjunctival sac of the patient’s eyes (eye) 2-3 times a day.
When applies conducts ophthalmoscopy installation single drug. Typically, enough to create mydriaza 1 drop drug instillation in the conjunctival sac. Maximum mydriasis achieved after 15-30 min minutes is maintained for 1-3 hours.
If necessary, the maintenance of mydriasis for a long time after 1 hour drug can re-install.
For diagnostic procedures applicable preparation single installation:

  • as provocative test in patients with narrow profile of anterior chamber angle of the eye and suspected closure glaucoma. If the difference between the values of intraocular pressure before instillation of the preparation and after pupil dilation is 3 to 5 mm Hg. . Art, the provocative test is considered positive;
  • for the differential diagnosis of the type of injection of the eyeball, if 5 minutes after the installation of the drug observed vasoconstriction of the eyeball, the injection is classified as surface, while maintaining the redness of the eyes should be carefully examine the patient for the presence of iridocyclitis or scleritis, as it shows the expansion of a more deep-lying vessels .
    to remove the accommodation spasm in children from 6 years of age and adults Installs the preparation 1 drop in each eye at night every day for 4 weeks.Side effects: the part of the organ of vision . Conjunctivitis, periorbital edema . In some cases, patients reported a burning sensation at the beginning of the application, blurred vision, irritation, discomfort in the eye, excessive tearing, increased intraocular pressure Fetsilefrin can cause reactive cramps the day after the application . Repeated instillation of drug in a short period of time can lead to a less pronounced mydriasis than nablyudavshiemusya earlier. This effect is often seen in elderly patients. As a result of a significant reduction in muscle dilates the pupil, 30-45 minutes after instillation of buy anavar under the influence of moisture in the anterior chamber can be detected pigment particles of pigment of the iris leaf. The slurry in the chamber moisture must be differentiated manifestations of anterior uveitis or to exposure to blood cells in the moisture of the anterior chamber. Systemic reactions of the skin and its appendages: contact dermatitis. Cardio-vascular system: palpitations, tachycardia, arrhythmia, increased blood pressure , ventricular arrhythmia, reflex bradycardia, coronary artery occlusion, pulmonary embolism.

    Overdose:

    Symptoms: anxiety, nervousness, dizziness, sweating, vomiting, palpitations, weak or shallow breathing. Treatment: when systemic action occurs buy anavar to stop undesirable effects can be achieved by the introduction of α-blockers, for example, 5-10 mg of phentolamine intravenously. If necessary, repeat injections.

    Interactions with other drugs:
    Midriatichesky fenylefrina effect is enhanced when used in combination with topical application of atropine. Due to the strengthening of vasopressor action may develop tachycardia.
    The use of buy anavar with monoamine oxidase inhibitors, as well as for 21 days after the termination of their use should be carried out with caution, as in this case, there is the possibility of an uncontrolled rise in blood pressure. Pressor effect of alpha-agonists may also be potentiated with concomitant use of tricyclic antidepressants, propranolol, reserpine, guanethidine, methyldopa and m-holinoblokatorami.
    buy anavar may potentiate the inhibition of cardiovascular activity during inhalation anesthesia.
    The simultaneous use of other agonists and sympathomimetics may potentiate the effect of buy anavar on the cardiovascular system.

     

    Special instructions:

    Exceeding the recommended dose of a 2.5% solution in patients with injuries, eye diseases or its appendages, in the postoperative period or at a reduced tear production (anesthesia) may lead to increased absorption of buy anavar th development of systemic side effects.

    Effects on ability to drive machinery and vehicles after use of the drug due to changes in the width of the pupil accommodation and may decrease visual acuity, so to restore it is not recommended to drive and engage in potentially hazardous activities that require high concentration and psychomotor speed reactions.