anavar steroid

Anavar steroid 1000 mg, 12.20 mg phenylephrine hydrochloride. Excipients powder blackcurrant – ascorbic acid, sucrose, citric acid, sodium citrate, aspartame, acesulfame potassium, blackcurrant flavor S-133747, blackcurrant flavor 1007348, dye blackcurrant. Excipients powdered lemon – ascorbic acid, sucrose, citric acid, sodium citrate, aspartame, acesulfame potassium, dye quinoline yellow, flavoring lemon F / 29088, flavoring lemon F / 29089, flavoring lemon F / 28151, flavoring lemon F / 501.476 / AP0504.

 

Description
Powder blackcurrant:. Crystalline powder light purple color with a characteristic smell of blackcurrant
powder lemon:. Crystalline powder of light yellow color with a characteristic lemon smell
solution powder blackcurrant: red-purple color with a characteristic smell of blackcurrant.
Citric powder: yellow with a characteristic odor of lemon, with opalescent.

 

Pharmacotherapeutic group:

The means to eliminate the symptoms of ARI and “cold” (non-narcotic analgesic agent + alpha-agonists).

Pharmacological properties 

Pharmacodynamics
. Combination drug action is due to the composition of its constituent components
anavar steroid has analgesic and antipyretic action, these effects are due to inhibition of prostaglandin synthesis in the central nervous system.
Phenylephrine – postsynaptic alpha adrenoceptor agonist with low affinity to a cardioselective beta-receptors. Decongestants, constricts blood vessels, eliminates swelling and hyperemia of the mucous membrane of the nasal cavity.

Pharmacokinetics:
anavar steroid is rapidly and completely absorbed in the small intestine. The maximum blood concentration is observed after 15-20 minutes after ingestion.Systemic bioavailability determined first pass metabolism, and, depending on dose, ranges from 70% to 90%. anavar steroid is rapidly distributed to all tissues of the body and has a half-life of approximately 2 hours. It is metabolized in the liver and excreted in the urine as glucuronide and sulfate compounds (> 80%).
Phenylephrine is rapidly absorbed from the gastrointestinal tract. The level of primary metabolism is high enough (≈60%), oral administration of phenylephrine therefore reduces its bioavailability (≈40%). The maximum plasma concentration occurs within 1-2 hours, and the half-life ranging from 2 to 3 hours. Return with urine in the form of sulphate compounds. Oral decongestant phenylephrine as should be carried out at intervals of 4-6 hours.

Indications
Symptoms “cold” and flu include headache, sore throat, and other types of pain, nasal congestion, increased body temperature.

Contraindications

 

  • Hypersensitivity to anavar steroid or other ingredients;
  • Arterial hypertension;
  • Cardiac ischemia;
  • Abnormal liver function and marked impairment of renal function;
  • Hyperthyroidism;
  • Diabetes;
  • Phenylketonuria (because the product contains aspartame);
  • Simultaneous treatment with tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), or beta-blockers or taking them during the last 2 weeks;
  • Pregnancy and lactation;
  • Prostatic hyperplasia;
  • Glaucoma;
  • Age up to 18 years;
  • Deficiency of sucrase / isomaltase;
  • Fructose intolerance;
  • Glucose-galactose malabsorption.The caution
    is not recommended long-term use of the drug. Avoid the simultaneous administration of other respiratory and / or anavar steroid-containing medicines. Do not take the medication simultaneously with alcohol intake.
    Bronchial asthma, COPD (chronic obstructive pulmonary disease), deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and rotor), hyperoxaluria.

    Use in pregnancy and breast-feeding
    should not use the drug during pregnancy and breastfeeding.

    Dosage and administration:
    Dissolve the contents of one sachet into a hot but not boiling water (250 ml). Allow to cool to an acceptable temperature and drink.
    Adults and children over 18 years – one bag. If necessary, repeat the reception every 4-6 hours, but not more than 4 doses (sachets) per day.
    The drug is not recommended to use more than 5 days as an analgesic and 3 days as antipyretic without consulting your doctor.
    If symptoms persist, should consult a doctor.

    Side effects anavar steroid
    Allergic reaction Rare: skin rash, urticaria, anaphylaxis, bronchospasm, angioedema. On the part of the central nervous system Rare: dizziness. Hematopoietic system Rare: aplastic anemia, methemoglobinemia, a blood pressure increase. Very rare: abnormal blood changes, such as thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia. From the digestive system Rare: nausea, vomiting, dryness of the oral mucosa, hepatotoxic effects. From the urinary system Rare: urinary retention, renal toxicity (papillary necrosis). Other rare: paresis of accommodation, increased intraocular pressure, mydriasis. Phenylephrine cardio-vascular system rare: tachycardia, increased blood pressure. From the nervous system rare: insomnia, nervousness, tremor, anxiety, irritability, confusion, irritability, and headache. digestive system Common: anorexia, nausea and vomiting. On the part of the immune system and the skin rare: allergic reactions, including skin rash, urticaria, anaphylaxis and bronchospasm.

    Overdose anavar steroid Liver damage is possible in adults who have taken 10 g or more of anavar steroid. Receive 5 or more grams of acetaminophen can cause liver damage if there are risk factors: long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin or other drugs that induce liver enzymes, alcohol abuse, lack of glyutaniona (eg, malnutrition), cystic fibrosis, HIV -infektsiya, starvation, cachexia. Symptoms of anavar steroid overdose in the first 24 hours:. pallor, nausea, vomiting, anorexia and abdominal pain liver damage can occur during the period from 12 to 48 hours after treatment. In case of overdose of anavar steroid, despite the absence of the primary symptoms of overdose, you should seek qualified help in medical facilities. To prevent severe consequences of overdose should promptly take the necessary measures. The symptoms may only manifest itself partly in the form of nausea or vomiting and may not reflect the real extent of overdose or the risk of organ damage. In severe overdose – liver failure with progressive encephalopathy, coma, and death; Acute renal failure with tubular necrosis (including the absence of severe liver damage); . arrhythmia, pancreatitisPhenylephrine Symptoms of phenylephrine overdose include irritability, headache, increased blood pressure. In the event of an overdose of the above symptoms should consult a doctor. Treatment: An Introduction donators of SH-groups and precursors of glutathione synthesis – methionine for 8-9 hours after overdose and acetylcysteine – for 8 hours. The need for additional therapeutic activities (further administration of methionine, acetylcysteine intravenous administration) is determined depending on the concentration of anavar steroid in the blood, and the time elapsed after the reception.

    Interaction with other drugs anavar steroid

    Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumetsinol, rifampin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication.
    anavar steroid intensifies the effect of indirect anticoagulants and reduces the effectiveness of urikozuricheskih drugs.
    The rate of absorption of anavar steroid is increased by the action of metoclopramide or domperidone, and reduced by the action of cholestyramine.
    anticoagulant effect of warfarin and coumarin dr.proizvodnyh increases with long-term use of anavar steroid.
    The drug enhances the effects of MAO inhibitors, sedatives, ethanol. phenylephrine with simultaneous use with phenylephrine antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives can be urinary retention, dryness of the oral mucosa, constipation. In the application of glucocorticosteroid with an increased risk of developing glaucoma. Tricyclic antidepressants increase the effect of phenylephrine adrenomimeticheskoe, co-administration of halothane increases the risk of ventricular arrhythmias.

    Special instructions:
    The drug should not be combined with the intake of ethanol.
    In the period of treatment should refrain from taking sleeping pills, antianxiety drugs, and other drugs containing acetaminophen.
    The drug distorts the results of the laboratory tests that assess the concentration of glucose and uric acid in plasma.
    Contains sucrose. The drug is contraindicated in patients with a rare congenital fructose intolerance, glucose malabsorption, galactose or sucrase-isomaltase difitsita.
    Contains aspartame (E951), a source of phenylalanine. It can be toxic to patients with phenylketonuria.
    When driving and other lesson potentially dangerous activities should be taken into account that the drug can cause side effects such as dizziness and confusion.

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