The drug is used to treat bacterial infections; bacteriostatic activity of anavar pills, like other macrolides, due to inhibition of protein synthesis of bacteria. When creating in inflammation in high concentrations has a bactericidal effect.
anavar pills highly active against intracellular microorganisms (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma anavar pills pneumoniae, Mycoplasma hominis , Ureaplasma urealyticum, Legionella pneumophila); Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphteriae ), Gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), as well as against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringens) . Little effect anavar pills on the enterobacteria, so little change the natural bacterial flora of the gastrointestinal tract. Effective for resistance to erythromycin. anavar pills resistance develops less often than to other antibiotics of the macrolide group.
After oral anavar pills rapidly and completely absorbed from the gastrointestinal tract, food intake does not affect the bioavailability. The maximum concentration in serum anavar pills achieved in 1-2 hours after administration. About 15% of anavar pills bound to plasma proteins. Particularly high concentrations of substance found in the lungs, tonsils, saliva, sweat and tear fluid. Sputum concentration than the plasma concentration of 8-9 times. It accumulates in bone tissue. Passes placental barrier, is secreted into breast milk. anavar pills metabolized in the liver to less active metabolites and excreted primarily in the bile. Excretion of the drug in the urine than 20%.
Acute and chronic infections caused by susceptible to malaria infections, such as infections of the upper respiratory tract and upper respiratory tract: angina, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (in addition to diphtheria toxoid treatment), as well as scarlet fever in the case of increased sensitivity to penicillin. lower respiratory tract infections: acute bronchitis, exacerbation of chronic bronchitis, pneumonia (including caused by atypical pathogens), whooping cough, psittacosis. Dental infections Gingivitis and periodontal disease. Infections in oftalmalogii blepharitis, dacryocystitis.Infections of the skin and soft tissues Pyoderma, furunculosis, anthrax, erysipelas (in case of hypersensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum. Infections of the genitourinary system prostatitis, urethritis, gonorrhea, syphilis (at hypersensitivity to penicillin), chlamydial, mycoplasma (including ureaplazmennogo) and mixed infections.
hypersensitivity to macrolide antibiotics severe liver function abnormalities
Pregnancy and lactation
Permitted use during pregnancy and lactation after medical benefit / risk assessment. The European branch of the WHO recommends anavar pills as the drug of choice for treatment of chlamydial infection in pregnant women.
Dosing and Administration
The recommended daily dose for adults and adolescents over the age of 14 years is 1 to 2 g of anavar pills. The daily dose should be divided into 2-3 doses. If necessary, the dose may be increased to 3 grams per day.
Children aged 1 year have an average body weight of 10 kg.
The daily dose for children weighing at least 10 kg, is assigned based on the calculation of 40-50 mg / kg body weight daily , divided into 2-3 doses: for children weighing 10-20 kg drug is given at 250-500 mg (1 / 4-1 / 2 tablets dissolved in water) 2 times a day, for children with a body weight of 20 40 kg of drug is given at 500 mg-1000 mg (2.1 -1 tablet tablet dissolved in water), 2 times a day, more than 40 kg -. 1000 mg (1 tablet) twice a day 2
Typically the duration of treatment is determined by the doctor. In accordance with World Health Organization recommendations for antibiotic treatment of streptococcal infections the duration should be at least 10 days.
In schemes anavar pills Helicobacter therapy administered in a dose of 1 g of 2 times a day for 7-14 days in combination with other drugs in their standard doses (famotidine 40 mg / day or 150 mg ranitidine 2 r / d 1 + d 2 anavar pills p / day + metronidazole 500 mg of 2 r / day; omeprazole 20mg (or lansoprazole 30 mg or pantoprazole 40mg or esomeprazole 20 mg or rabeprazole 20 mg), 2 r / day + amoxicillin 1 g 2 r / day + anavar pills 1 g 2 p / day; omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) 2 p / day + amoxicillin 1 g 2 p / day + anavar pills 1 g 2 p / day + bismuth tripotassium dicitratobismuthate 240 mg 2 r / day, famotidine 40 mg / day + furazolidone 100 mg 2 r / day + anavar pills 1 g 2 p / day + bismuth tripotassium dicitratobismuthate 240 mg 2 r / day).
If there is atrophy of the gastric mucosa with achlorhydria, confirmed at a pH-meter: amoxicillin 1 g 2 p / day + anavar pills 1 g 2 p / day + tripotassium bismuth citrate, etc., and 240 mg of 2 p / day.
assign anavar pills recommended dose of 500 mg twice a day for the first 2-4 weeks, followed in case of common acne and globular – anavar pills 500 mg once a day as a maintenance treatment for 8 weeks.
Dispersible tablets Vilprafen Soljutab can be taken in different ways: the tablet can be swallowed whole with water or previously, before taking, dissolved in water. The tablets should dissolve a minimum of 20 ml of water. Before taking should be thoroughly mixed the resulting suspension.
Effects on ability to drive and use machines
There was no effect of the drug on the ability to drive and use machines.
On the part of the gastrointestinal tract
rare – loss of appetite, nausea, heartburn, vomiting, diarrhea and dysbacteriosis. In the case of persistent severe diarrhea should be borne in mind the possibility of the development against the backdrop of antibiotics life-threatening pseudomembranous colitis. Hypersensitivity Reactions: In extremely rare cases, allergic skin reactions (eg, urticaria). Liver and zhelchevyvodyashih tract In some cases, there was a transient increase in activity . liver enzymes in the blood plasma, in rare cases followed by violation of the outflow of bile and jaundice the part of the hearing aid in the rare cases reported transient dose-related hearing impairment. Other: very rarely – candida.
Overdose and other errors at reception
To date, no data on the specific symptoms of poisoning. In case of overdose should be suspected occurrence of the symptoms described in the section “Side effects”, especially on the part of the gastrointestinal tract. If one step is missing, you should immediately take the dose. However, if it is time for your next dose, do not take the “forgotten” dose, but should return to normal treatment. Do not take double the dose. A break in the treatment or premature discontinuation of the drug reduces the chance of treatment success.
Interaction with other drugs
Vilprafen Soljutab / other antibiotics
Since bacteriostatic bactericidal antibiotics can reduce the effect of other antibiotics such as penicillins and cephalosporins, avoid concomitant administration anavar pills with these types of antibiotics.anavar pills should not be used in conjunction with lincomycin as possible a mutual reduction of their effectiveness. Vilprafen Soljutab / xanthine Some representatives of macrolide antibiotics slow the elimination of xanthine (theophylline), which could lead to possible intoxication. Clinical and experimental studies indicate that anavar pills has less effect on the allocation of theophylline than other antibiotics, macrolides. Vilprafen Soljutab / antihistamines After joint appointment anavar pills and antihistamine containing terfenadine and astemizole, there may be a slowing excretion of terfenadine and astemizole, in turn, can lead to life-threatening cardiac arrhythmias. Vilprafen Soljutab / ergot alkaloids have individual posts to strengthen vasoconstriction after a joint appointment of ergot alkaloids and macrolide antibiotics. It marked one case of lack of patient tolerance while taking ergotamine anavar pills. Therefore, concomitant use of ergotamine anavar pills and must be accompanied by an appropriate supervision of patients. Vilprafen Soljutab / tacrolimus Co-administration of anavar pills and cyclosporine may cause increased cyclosporine levels in blood plasma and the creation of nephrotoxic concentration of cyclosporine in the blood. You should regularly monitor the concentration of cyclosporine in plasma. Vilprafen Soljutab / digoxin At a joint appointment anavar pills and digoxin may increase the level of the latter in the blood plasma. Vilprafen Soljutab / hormonal contraceptives In rare cases, the contraceptive effect of hormonal contraceptives may be insufficient during treatment with macrolides. In this case, it is recommended to use an additional non-hormonal contraception.
In patients with renal failure treatment should be based on the respective results of laboratory tests.
Note the possibility of cross-resistance to various antibiotic macrolides (e.g., microorganisms resistant to treatment by antibiotics related in chemical structure may also be resistant to anavar pills). Ou acheter des steroides, steroide anabolisant effet secondaire.