Antibiotic produced by spore-forming bacteria of Bacillus polymyxa . Each mg of purified anavar only cycle base is equivalent to 10,000 units of anavar only cycle. It has bactericidal action associated with the violation of the integrity of the bacterial cell membrane. Phospholipids adsorbed on membrane permeability increases, causing bacteria lysis. It is active against most Gram-negative bacteria, including Pseudomonas aeruginosa, Salmonella spp., Shigella spp., Escherichia coli, Klebsiella spp., Bordetella pertussis, Haemophilus influenzae, Enterobacter spp. Moderately susceptible by Fusobacterium spp. spp and Bacteroides. (including Bacteroides fragilis ). No effect on aerobic cocci ( Staphylococcus spp., Streptococcus spp. (IncludingStreptococcus pneumoniae ), Neisseria gonorrhoeae, Neisseria meningitidis ) and anaerobic bacteria, Corynebacterium diphtheriae , for most strains of Proteus spp., Mycobacterium tuberculosis , and fungi. Resistance develops slowly, but it is a cross to colistin and polymyxin E.
When injecting a maximum plasma concentration of 2-7 mg / ml, achieved after 1-2 h; at / in a dose of 2-4 mg / kg, the maximum plasma concentration – 2-8 mg / ml. Communication with plasma proteins – 50%. Poorly penetrated through tissue barriers, can not penetrate the blood-brain barrier. Small amounts cross the placenta and breast milk. Do not metabolized. Excreted by the kidneys in unchanged form (60% for 3-4 days), and through the intestines. The half-life is 3-4 hours, in severe renal insufficiency – 2-3 days. Repeated administration does not accumulates.
Indications for use
Severe infections caused by susceptible to polymyxin in gram-negative organisms with multiple resistance to other antibiotics: sepsis, meningitis (administered intrathecal), pneumonia, skin and soft tissue infections, including wound infection, infection in baked.
Hypersensitivity to polymyxin, myasthenia gravis.
Precautions for the use
of side effects of anavar only cycle may be renal dysfunction (nephrotoxicity) and nervous system (neurotoxicity), the risk of which is higher in patients with chronic renal failure and / or concomitant use with other drugs having neurotoxic and / or nephrotoxic properties.
Vilimiksin ® should be used with caution in patients with chronic kidney failure.
avoid the simultaneous application of the drug Vilimiksin ® with other neuro-and nephrotoxic drugs.
Use during pregnancy and breast-feeding
is contraindicated during pregnancy.
If necessary, use during lactation should abandon breastfeeding.
Dosing and Administration
Intravenous (w / w), intramuscular (i / m), intrathecally. Intravenously : adults and children older than 1 year at a daily dose of 1.5-2.5 mg / kg, which is divided into two administration intervals 12 hours. The maximum daily dose should not exceed 2.5 mg / kg. in children younger than 1 year with normal renal function, the daily dose may be increased to 4 mg / kg, which is divided into two injection every 12 hours. The solution for the on / administration is prepared in two steps: 1) a vial of dry powder of the antibiotic was added 5.3 mL sterile water for injection or 5% dextrose solution; 2) the resulting solution was transferred to a vial containing 300-500 ml 5% dextrose solution; introducing drip at a rate of 60-80 drops / min. In children, the amount of solvent (5% dextrose) is reduced in proportion to the dose;introducing drip at a rate of 30-60 drops / min or slower. Intramuscular : for adults and children older than 1 year at a daily dose of 2.5-3.0 mg / kg, which is divided into 3-4 injection with an interval of 6-8 hours . in children younger than 1 year with normal renal function, the daily dose may be increased to 4 mg / kg, which is divided into 4 injections with an interval of 6 hours. for the / m of a sterile powder of the antibiotic (25 mg and 50 mg) were dissolved in 2 ml 0.5-1% solution of procaine, water for injection or 0.9% sodium chloride solution. The resulting solution is injected deep intramuscularly in the areas of the body with pronounced muscular layer, for example, in verhnenaruzhnogo quadrant of the buttocks or lateral thigh. In children younger than 1 year of intramuscular administration of the drug Vilimiksin ® is indicated only when it is impossible intravenous administration. In patients with impaired renal function reduce the dose and increase the interval between doses according to creatinine clearance, as shown in the table.
ml / min
|% Of the dose in normal
|The interval between
|less than 5||15||12|
Intrathecal administration is the treatment of choice in meningitis caused by P. aeruginosa. Before administration of 25 mg or 50 mg of dry powder of the antibiotic is dissolved in 10 ml of water for injection.Adults and children over 2 years of age are administered 5 mg 1 time per day for 3-4 days, followed by 5 mg 1 time in 2 days; Children up to 2 years – 2 mg / day for 3-4 days, or 2.5 mg 1 time in 2 days.Treatment was continued for two weeks after receiving a negative result and normalization bacteriological seeding glucose concentration in the cerebrospinal fluid.
Side effect On the part of the nervous system : dizziness, ataxia, impaired consciousness, drowsiness, paresthesia, neuromuscular blockade. From the urinary system : albuminuria, cylindruria, azotemia, proteinuria, renal tubular necrosis. The respiratory system : paralysis of the respiratory muscles, sleep apnea . From the digestive system : epigastric pain, nausea, decreased appetite. From the senses : blurred vision. Allergic reactions : skin rash, pruritus, eosinophilia. Local reactions : phlebitis, periflebit, thrombophlebitis, pain at the site of the / m injection . Other : superinfection, candidiasis, intrathecal – meningeal symptoms.
Overdose symptoms : paralysis of the respiratory muscles, ototoxicity, nephrotoxicity. Treatment : supportive and symptomatic therapy.
Interaction with other medicinal products
is incompatible with the non-depolarizing muscle relaxants (threat of paralysis of the respiratory muscles).
When applied simultaneously observed synergistic effect with chloramphenicol, carbenicillin, tetracycline, sulfonamides and trimethoprim against Pseudomonas aeruginosa, Proteus spp, Serratia spp .;. Ampicillin – in for most Gram-negative bacteria.
Compatible with bacitracin and nystatin.
In combination with aminoglycosides (kanamycin, streptomycin, neomycin, gentamicin) increases the risk of Oto-and nephrotoxicity, as well as the blockade of neuromuscular transmission. Increases nephrotoxicity of amphotericin B.
Pharmaceutical incompatible with the sodium salt of ampicillin, chloramphenicol, cephalosporin antibiotics group, tetracycline, amino acid solutions, heparin; they should not be mixed in the same syringe or infusion medium.
When infections caused by Gram-negative organisms ( of Enterobacter, of Pseudomonas aeruginosa , and others.), Appointed only for the stability of the pathogen to other less toxic antimicrobial. Prolonged treatment is necessary to monitor kidney function 1 time in 2 days. Parenteral used only in a hospital. Intramuscular injections are painful, so it is recommended to use a local anesthetic (1% procaine solution) for solution for i / m administration.
The impact on performance of potentially hazardous activities that require attention and speed of reactions
There are no data indicating negative effect of anavar only cycle on the ability to drive vehicles and other classes of potentially hazardous activities that require high concentration and psychomotor speed reactions.
Powder for solution for injection 25 mg and 50 mg. At 25 and 50 mg of the active substance in glass bottles with a capacity of 10 ml, sealed with rubber stoppers made of rubber, aluminum crimped caps or imported or combined (aluminum with safety plastic covers). On safety plastic lid embossed applied «ABOLmed» or without embossing. Each vial is glued label sensor radio RFID-RFID tag or without sensor.
Solvent -. “Water for injection” in glass ampoules 5 ml
1 vial and instructions for use placed in a pile of cardboard.
1 vial and 1 ampule the solvent is packaged in blisters. One contour cell package and instructions for use are investing in paper cartons.
5 vials of the drug is packaged in blisters. One contour cell package and instructions for use are investing in paper cartons.
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